Stat2 rabbit pAb

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],

STAT2; Signal transducer and activator of transcription 2; p113

6773

P52630

Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta..

Rabbit

Human,Mouse,Rat

The antiserum was produced against synthesized peptide derived from human STAT2. AA range:656-705

Polyclonal

WB,IP,IHC,IF,ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

113kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.