Topo I rabbit pAb

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008],

TOP1; DNA topoisomerase 1; DNA topoisomerase I

7150

P11387

Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli.

Rabbit

Human, Mouse, Rat

Synthesized peptide derived from the Internal region of human Topo I.

Polyclonal

WB, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

90kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.