TP53INP1 rabbit pAb

Function: In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. induction: By adriamycin, gamma irradiation and H (2)O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation. subcellular location: Concentrated in PML/POD/ND10 nuclear bodies. subunit: Interacts with TP53 and HIPK2. tissue specificity: Ubiquitously expressed.

TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1

94241

Q96A56

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Rabbit

Human, Rat, Mouse,

The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220

Polyclonal

WB, IHC, IF, ELISA

1 year

1 mg/mL

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

27kD

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.