Anti-VLDL-Receptor (Very Low Density Lipoprotein Receptor) (VLDLR/1337), CF640R conjugate

VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Very low-density lipoprotein receptor; VLDL receptor; VLDL-R; VLDLR

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

VLDLR

7436 (Human)

370422 (Human)

P98155 (Human)

Plasma membrane

Mouse

Human, Rat

Recombinant human VLDLR fragment from c-terminal (exact sequence is proprietary)

VLDL Receptor

Monoclonal

IgG1

VLDLR/1337

CF640R

Animal

IHC, FFPE (verified)

IHC, FFPE

Metabolism

HeLa or U-251 cells. Pancreas, Cerebellum, Heart or Skeletal Muscle.

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

143-161 kDa

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Immunohistology (formalin) 1-2 ug/mL|Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA pH 9.0 for 10-20 min followed by cooling at RT for 20 min|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Western blotting 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years

Primary

https://biotium.com/product/mouse-monoclonal-anti-vldl-receptor-vldlr1337