ZM447439

ZM447439 is a potent and selective inhibitor of Aurora B kinase. ZM447439 induces cell growth arrest mid-way through mitosis, and therefore effectively activates apoptosis.

Aurora B kinase inhibitor

ZM 447439, N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

331771-20-1

41116105

Synthetic

≥98% (TLC); NMR (Conforms)

0.001

Orange solid

May be dissolved in DMSO (50mg/mL)

C29H31N5O4

513.6

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Walsby E., Walsh V., Pepper C., Burnett A., & Mills K. (2008) Haematologica. 93(5): 662–669.
2. Kim K.W., et al. (2007) Int. J. Rad.Oncol. Biol. Phy. 67(5): 1519–1525.

Small Molecules

Inhibitor

https://www.stressmarq.com/products/small-molecules/zm447439-sih-489/

Canada