Filaggrin Antibody

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

P20930

Mouse

A portion of amino acids 998-1104 from the human protein was used as the immunogen for the Filaggrin antibody.

Monoclonal

IgG2b κ

IHC-P

Biotin Conjugate

0.1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Store the Filaggrin antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

This Filaggrin antibody is available for research use only.