Anti-IGF-1(IGF1/1020), CF488A conjugate

This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Insulin-like Growth Factor IA (IGF-IA); Insulin-like Growth Factor IB (IGF-IB); Mechano Growth Factor (MGF); Somatomedin-C

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

IGF1

3479

160562

P05019

Secreted (extracellular)

Mouse

Human,Mouse,Rabbit,Rat

Full-length recombinant human IGF-1 protein

IGF-1

Monoclonal

IgG1 κ

IGF1/1020

CF488A

Animal

IF (verified)

IF

Cancer, Signal transduction

Pancreas or brain. Breast, Thyroid or Colon Cancers; IGF-1 recombinant protein

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

~7.6 kDa

Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 1-2 ug/mL|Flow Cytometry 0.5-1 ug/million cells/0.1 mL|Optimal dilution for a specific application should be determined by user

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years