p65 Antibody (RELA)

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivates NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs. [OMIM]

Q04206

Rabbit

A portion of amino acids 517-539 from the human protein was used as the immunogen for this p65 antibody.

Polyclonal

Ig

IF, WB, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the p65 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This p65 antibody is available for research use only.