Clostridium difficile Toxin A Antibody

This mAb reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.

P16154

Mouse

C. difficile Toxin A was used as the immunogen for the Clostridium difficile Toxin A antibody.

Monoclonal

IgG1 κ

ELISA, IF

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Clostridium difficile Toxin A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Clostridium difficile Toxin A antibody is available for research use only.