Anti-Ki-67 (Proliferating Cell Marker)(MKI67/2463), CF488A conjugate

Ki-67 antigen is a nuclear, non-histone protein that is present in all stages of the cell cycle except G0. This characteristic makes Ki-67 an excellent marker for proliferating cells and is commonly used as one of the prognostic factors in cancer studies. A correlation has been demonstrated between Ki-67 index and the histo-pathological grade of neoplasms. Assessment of Ki-67 expression in renal and ureter tumors shows a correlation between tumor proliferation and disease progression, thus making it possible to differentiate high-risk patients. Ki-67 expression may also prove to be important for distinguishing between malignant and benign peripheral nerve sheath tumors. Ki-67 labeling index has been shown to be a prognostic marker in a number of neoplasms including grade II astrocytoma, oligodendroglioma, colon carcinoma, and breast carcinoma. In general, Ki-67 is a good marker of proliferating cell populations. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

KI-67; Ki67; KI-67 Antigen (KIA); MKI67; Proliferation related Ki-67 antigen

41116161

Primary and secondary antibodies for multiple methodology
immunostaining detection application

MKI67

4288

689823

P46013

Nucleus

Mouse

Human

Recombinant fragment of human Ki67 protein (around aa 2293-2478) (exact sequence is proprietary)

Ki-67

Monoclonal

IgG1 κ

MKI67/2463

CF488A

Tumor

Animal

Flow, intracellular (verified) | IHC, FFPE (verified) | WB (verified)

FC,IHC,FFPE,WB

Any actively proliferating cells. Skin, Tonsil or Lymph Node

0.1 mg/mL

PBS, 0.1% BSA, 0.05% azide

345 kDa and 395 kDa

Room temperature

4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

2 years