DCK Antibody / Deoxycytidine kinase

Deoxycytidine kinase is responsible for the phosphorylation of several deoxyribonucleosides and their analogs. Deficiency of this enzyme activity is associated with resistance to antiviral and anticancer chemotherapeutic agents, whereas increased enzyme activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. It is the rate limiting enzyme in the activation of many important anticancer and retroviral drugs and its activity is often decreased in cells that are resistant to cytosine arabinoside.

P27707

Rabbit

A portion of amino acids 171-200 from the human protein was used as the immunogen for the Deoxycytidine kinase antibody.

Polyclonal

Ig

WB, IF, IHC-P

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Deoxycytidine kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Deoxycytidine kinase antibody is available for research use only.