B7-H3 Antibody / CD276

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

Q5ZPR3

Mouse

Recombinant human protein was used as the immunogen for the B7-H3 antibody.

Monoclonal

IgG1 κ

WB, IHC-P, ICC

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the B7-H3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This B7-H3 antibody is available for research use only.