Filaggrin Recombinant Antibody

Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

P20930

Mouse

Amino acids 198-288 of human FLG were used as the immunogen for this recombinant Filaggrin antibody.

Monoclonal

IgG1 κ

Recombinant

IHC-P

Purified

Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

Store the recombinant Filaggrin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This recombinant Filaggrin antibody is available for research use only.