Mineralocorticoid Receptor Antibody / MR / NR3C2

Mineralocorticoid hormones are primarily found in epithelial tissues where they function as regulators of Na+, K+ and H+ ion transport. Aldosterone is a mineralocorticoid that has been shown to regulate electrolyte excretion and intravascular volume and is therefore involved in blood pressure regulation. Mineralocorticoid receptor (MCR or MR) is a member of the steroid/thyroid/ retinoic nuclear hormone receptor superfamily that has been shown to activate gene transcription in response to aldosterone binding. Regulation of the mineralocorticoid receptors occurs through either receptor downregulation (negative autoregulation) or hormone-mediated upregulation (positive autoregulation). MCR association with HSP 90 appears to be required for hormone binding to MCR and subsequent MCR activation.

P08235

Mouse

A recombinant partial protein sequence (within amino acids 601-673) from the human protein was used as the immunogen for the Mineralocorticoid Receptor antibody.

Monoclonal

IgG1 κ

IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the Mineralocorticoid Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Mineralocorticoid Receptor antibody is available for research use only.