SDHB Antibody / Succinate dehydrogenase B

Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation. Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.

P21912

Mouse

A recombinant human SDHB protein fragment (within amino acids 165-273) was used as the immunogen for the Succinate dehydrogenase B antibody.

Monoclonal

IgG2a κ

IF, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the Succinate dehydrogenase B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Succinate dehydrogenase B antibody is available for research use only.