C3d / Complement 3d Antibody

The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH- and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.

P01024

Mouse

A portion of amino acids 1250-1450 from human Complement C3 protein was used as the immunogen for this Complement 3d antibody.

Monoclonal

IgG2b κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Complement 3d antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Complement 3d antibody is available for research use only.