Bcl-2 Antibody

Bcl2 suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. [UniProt]

P10415

Mouse

Recombinant full-length human protein was used as the immunogen for the Bcl2 antibody.

Monoclonal

IgG1 κ

WB, IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Store the Bcl2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Bcl2 antibody is available for research use only.