NSE Antibody / Neuron Specific Enolase

This monoclonal antibody recognizes a protein of about 50kDa, which is identified as gamma-enolase. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue whereas gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE-gamma is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.

P09104

Mouse

A recombinant fragment of human NSE gamma (within amino acids 416-433) was used as the immunogen for the Gamma Enolase antibody.

Monoclonal

IgG2b κ

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Aliquot the Gamma Enolase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Gamma Enolase antibody is available for research use only.