Cyclophilin D Antibody

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.

Q08752

Rabbit

A portion of amino acids 336-370 from the human protein was used as the immunogen for the Cyclophilin D antibody.

Polyclonal

Ig

WB, FACS, IHC-P, IF

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Cyclophilin D antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Cyclophilin D antibody is available for research use only.