APP Antibody

The APP gene encodes Amyloid beta, a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

P05067

Rabbit

A portion of amino acids 333-362 from the human protein was used as the immunogen for this anti-APP antibody.

Polyclonal

Ig

IF, IHC, WB, ELISA

Antigen affinity purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the anti-APP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This anti-APP antibody is available for research use only.