CTSD Antibody / Cathepsin D

Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 52kDa preprocathepsin D that is cleaved and glycosylated to form a 48kDa procathepsin D and then further cleaved to produce 34kDa and 14kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease.

P07339

Mouse

Amino acids 104-250 were used as the immunogen of the Cathepsin D antibody.

Monoclonal

IgG1 κ

IHC-P, WB

Purified

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Store the Cathepsin D antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Cathepsin D antibody is available for research use only.