CD40 Antibody

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

P27512

Rat

Purified recombinant Mouse CD40 fusion protein was used as the immunogen for the CD40 antibody.

Monoclonal

IgG2a κ

Functional Studies, FACS, IF

Purified

0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Store the CD40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This CD40 antibody is available for research use only.