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Complement Factor B Antibody / CFB

CAT:R32391Size:100 µgPrice:Ask for quotation
Availability:
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Shipping:
This product ships with dry ice.
Description:

Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

UniProt:

P00751

Host:

Rabbit

Immunogen:

Amino acids E518-L764 from the human protein were used as the immunogen for the Complement Factor B antibody.

Clonality:

Polyclonal

Isotype:

IgG

Applications:

WB, IHC-P

Format:

Antigen affinity purified

Buffer:

0.5mg/ml if reconstituted with 0.2ml sterile DI water

Reconstitution:

After reconstitution, the Complement Factor B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations:

This Complement Factor B antibody is available for research use only.

Product Picture:
Image 1

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