FAS Antibody (phospho-Y291)

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]

P25445

Rabbit

This phospho-FAS antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY291 of human FAS.

Polyclonal

Ig

DB, ELISA

Antigen affinity purified

In 1X PBS pH 7.4 with 0.09% sodium azide

Aliquot the phospho-FAS antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This phospho-FAS antibody is available for research use only.