FOXP3 Recombinant Antibody / Scurfin

The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.

Q9BZS1

Rabbit

A recombinant partial protein sequence (within amino acids 300-431) from the human protein was used as the immunogen for the Forkhead box protein P3 antibody.

Monoclonal

IgG κ

Recombinant

IHC-P

Purified

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Aliquot the Forkhead box protein P3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Forkhead box protein P3 antibody is available for research use only.