HER2 Antibody / ErbB2 / C-terminal region

ErbB2, a member of the EGF receptor family, is an essential component of a neuregulin-receptor complex, althought neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. This protein is not activated by EGF, TGF-alpha and amphiregulin. ErbB2 potentially forms a heterodimer with each of the other ERBB receptors. An interaction with PRKCABP has been suggested. Ligand-binding to this Type I membrane protein may increase phosphorylation on tyrosine residues.

P04626

Rabbit

A portion of amino acids 1206-1236 from the human protein was used as the immunogen for the ErbB2 antibody.

Polyclonal

Ig

IHC-P, WB

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the ErbB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This ErbB2 antibody is available for research use only.