MUC1 Recombinant Antibody / Mucin-1

This MAb reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. It is used as tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of this MAb involves both amino acids as well as sugar moieties. Its epitope is destroyed by desialylation i.e. treatment with Neuraminidase.

P15941

Rabbit

Human milk fat globule membranes were used as the immunogen for this recombinant Mucin-1 antibody.

Monoclonal

IgG κ

Recombinant

IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the recombinant Mucin-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This recombinant Mucin-1 antibody is available for research use only.