Claudin 1 Antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

O95832

Rabbit

A portion of amino acids 40-82 from the human protein (loop 1) was used as the immunogen for this Claudin 1 antibody.

Polyclonal

Ig

WB, IHC, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Claudin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Claudin 1 antibody is available for research use only.