Thymidylate Synthase Antibody

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

P04818

Rabbit

A portion of amino acids 265-294 from the human protein was used as the immunogen for the Thymidylate Synthase Antibody.

Polyclonal

Ig

WB, IHC-P, IF, FACS

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Thymidylate Synthase antibody is available for research use only.