Anti-Hu TROP2 Purified

TROP2 is a cell surface receptor that transduces calcium signals. It belongs to carcinoma-associated antigens. Mutations of TROP2 have been associated with gelatinous drop-like corneal dystrophy.

The mouse monoclonal antibody TrMab-6 recognizes an extracellular epitope of TROP2, a type I transmembrane glycoprotein. This antibody is usefull for detection of TROP2 in breast cancer.

RUO

Mouse

Pig, Human

Mouse

TROP2-transfected CHO cells

TROP2

IgG2b κ

TrMab-6

Flow cytometry: Recommended dilution: 1-4 μg/mL.Western blotting: Recommended dilution: 1 μg/mL.Immunocytochemistry: Recommended dilution: 10 μg/mL the cells can be fixed with 4% PFA and permeabilized with 0.1% Triton X-100 before antibody staining, when needed. Immunohistochemistry (paraffin sections): Recommended dilution: 10 μg/mL. Heat-mediated antigen retrieval in citrate buffer, pH = 6.

WB, FC, IHC, ICC

1 mg/mL

Purified

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Sayama Y, Kaneko MK, Kato Y: Development and characterization of TrMab‑6, a novel anti‑TROP2 monoclonal antibody for antigen detection in breast cancer. Mol Med Rep. 2021 Feb23(2):92., URL: https://pubmed.ncbi.nlm.nih.gov/33300065/,

Store at 2-8°C. Do not freeze.