Thioredoxin Antibody

Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide _x0013_isomerase(PDI) and a number of transcription factors such as p53, NF-kB and AP-1.Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.

P10599

Rabbit

A portion of amino acids 1-30 from the human protein was used as the immunogen for this Thioredoxin antibody.

Polyclonal

Ig

WB, ELISA

Purified

In 1X PBS, pH 7.4, with 0.09% sodium azide

Aliquot the Thioredoxin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

This Thioredoxin antibody is available for research use only.