Cyclin D1 Antibody / CCND1

Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

P24385

Mouse

Recombinant human protein was used as the immunogen for the Cyclin D1 antibody.

Monoclonal

IgG2a κ

FACS, IHC-P

Purified

1 mg/ml in 1X PBS; BSA free, sodium azide free

Store the Cyclin D1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

This Cyclin D1 antibody is available for research use only.