Description of target: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:O70624 (MYOC_MOUSE)8 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.24"Mitochondrial association of myocilin, product of a glaucoma gene, in human trabecular meshwork cells."_x005F_x005F_x000D_Sakai H., Shen X., Koga T., Park B.C., Noskina Y., Tibudan M., Yue B.Y._x005F_x005F_x000D_J. Cell. Physiol. 213:775-784(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN MITOCHONDRIAL DEPOLARIZATION, SUBCELLULAR LOCATION.Ref.25"Rho GTPase and cAMP/protein kinase A signaling mediates myocilin-induced alterations in cultured human trabecular meshwork cells."_x005F_x005F_x000D_Shen X., Koga T., Park B.C., SundarRaj N., Yue B.Y._x005F_x005F_x000D_J. Biol. Chem. 283:603-612(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN CELL-MATRIX ADHESION.Ref.26"Myocilin promotes substrate adhesion, spreading and formation of focal contacts in podocytes and mesangial cells."_x005F_x005F_x000D_Goldwich A., Scholz M., Tamm E.R._x005F_x005F_x000D_Histochem. Cell Biol. 131:167-180(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN CELL ADHESION.Ref.27"Myocilin is a modulator of Wnt signaling."_x005F_x005F_x000D_Kwon H.S., Lee H.S., Ji Y., Rubin J.S., Tomarev S.I._x005F_x005F_x000D_Mol. Cell. Biol. 29:2139-2154(2009) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN STRESS FIBER ASSEMBLY, INTERACTION WITH FRZB; FZD7; FZD10; FZD1 AND WIF1, CHARACTERIZATION OF VARIANT ASN-477.Ref.28"Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth."_x005F_x005F_x000D_Koga T., Shen X., Park J.S., Qiu Y., Park B.C., Shyam R., Yue B.Y._x005F_x005F_x000D_Am. J. Pathol. 176:343-352(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN NEURITE OUTGROWTH.Ref.29"Myocilin, a glaucoma-associated protein, promotes cell migration through activation of integrin-focal adhesion kinase-serine/threonine kinase signaling pathway."_x005F_x005F_x000D_Kwon H.S., Tomarev S.I._x005F_x005F_x000D_J. Cell. Physiol. 226:3392-3402(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN CELL MIGRATION.Ref.30"Myocilin stimulates osteogenic differentiation of mesenchymal stem cells through mitogen-activated protein kinase signaling."_x005F_x005F_x000D_Kwon H.S., Johnson T.V., Tomarev S.I._x005F_x005F_x000D_J. Biol. Chem. 288:16882-16894(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION.Ref.31"Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."_x005F_x005F_x000D_Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I._x005F_x005F_x000D_J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN MYELINATION, INTERACTION WITH NFASC; GLDN AND NRCAM. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.26 ng/mL