Description of target: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro.3 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.1"A peptidoglycan recognition protein in innate immunity conserved from insects to humans."_x005F_x005F_x000D_Kang D., Liu G., Lundstroem A., Gelius E., Steiner H._x005F_x005F_x000D_Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.Ref.2"Molecular cloning and characterization of the mouse tag7 gene encoding a novel cytokine."_x005F_x005F_x000D_Kiselev S.L., Kustikova O.S., Korobko E.V., Prokhortchouk E.B., Kabishev A.A., Lukanidin E.M., Georgiev G.P._x005F_x005F_x000D_J. Biol. Chem. 273:18633-18639(1998) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, SUBCELLULAR LOCATION.Ref.4"Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic Gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)-deficient mice."_x005F_x005F_x000D_Dziarski R., Platt K.A., Gelius E., Steiner H., Gupta D._x005F_x005F_x000D_Blood 102:689-697(2003) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 5.9 pg/mL