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EndoG Antibody [7F2G10]

CAT:PM-4583-01mgSize:0.1 mgPrice:Ask for quotation
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EndoG Antibody [7F2G10]

Product Description:

EndoG Monoclonal Antibody: The fragmentation of nuclear DNA is a hallmark of apoptotic cell death. The activities of caspase and nuclease are involved in the DNA fragmentation. Caspase-activated deoxyribonuclease (CAD), also termed DNA fragmentation factor (DFF40), is one such nuclease, and is capable of inducing DNA fragmentation and chromatin condensation after cleavage by caspase-3 of its inhibitor ICAD/DFF45. Caspase and CAD independent DNA fragmentation also exists. Recent studies demonstrated that another nuclease, endonuclease G (EndoG), is specifically activated by apoptotic stimuli and is able to induce nucleosomal fragmentation of DNA independently of caspase and DFF/CAD. EndoG is a mitochondrion-specific nuclease that translocates to the nucleus and cleaves chromatin DNA during apoptosis. The homologue of mammalian EndoG is the first mitochondrial protein identified to be involved in apoptosis in <i>C. elegans</i>. EndoG also cleaves DNA in vitro.

Specifications:

Research area: Apoptosis

Host species: Mouse

Species reactivity: Human, Rat

Homology: N/A

Immunogen: Recombinant protein corresponding to amino acids 51 - 140 of human EndoG.

Tested Applications: E, WB

Applications: EndoG monoclonal monoclonal antibody can be used for detection of EndoG by Western blot at 5 - 10 &#956

g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Specificity: N/A

Positive control 1: Cat. No. 1211 - HepG2 Cell Lysate

Positive control 2: Cat. No. 95-103 - EndoG Recombinant Protein

Positive control 3: N/A

Positive control 4: N/A

Positive control 5: N/A

Positive control 6: N/A

Predicted molecular weight: N/A

MW explanation: N/A

Validation: N/A

Isoforms: N/A

Purification: EndoG Monoclonal Antibody is Protein A purified.

Clonality: Monoclonal

Clone: 7F2G10

Isotype: IgG1

Conjugate: Unconjugated

Physical state: Liquid

Buffer: EndoG Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

NCBI official symbol: ENDOG

Accession #: Q14249

Protein GI #: 24638471

NCBI gene ID#: 2021

NCBI official full name: endonuclease G

NCBI organism: Homo sapiens

SWISSPROT #: Q14249

Storage and shipping:

EndoG monoclonal antibody can be stored at -20&#730;C, stable for one year.

Additional informations:

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Notes:

Optimal dilutions for each application to be determined by the researcher.

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