[KD Validated] Bid Rabbit mAb

Seller Gentaur · Catalog number: A23234

Category product: Business and Industry > Scientific and Laboratory Research

 (0) Reviews

Price

1532.77 USD*

• Details

• Specifications: Monoclonal Antibodies
• Storage and shipping: Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
• Notes:
  • P21
  • CIP1
  • SDI1
  • WAF1
  • CAP20
  • CDKN1
  • MDA-6
  • p21CIP1
• Additional information:
  • This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively
  • it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.