Recombinant Human Serpin E1 Protein

Seller Gentaur · Catalog number: RP00532

Category product: Business and Industry > Scientific and Laboratory Research

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Price

2041.28 USD*

• Details

• Specifications: Proteins
• Storage and shipping:
  • Store the lyophilized protein at -20°C to -80 °C for long term.
  • After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
• Notes: this product is available in other different size, please contact us for more information
• Additional information: Serpins are a group of proteins with similar structures that were first identified as a set of proteins able toinhibit proteases. They are the largest and most diverse family of serine protease inhibitors which are involvedin a number of fundamental biological processes such as blood coagulation, complement activation,fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.Serpin E1 is a secreted protein which belongs to the Serpin family. Serpin E1 acts as 'bait' for tissueplasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major controlpoint in the regulation of fibrinolysis. Defects in SERPINE1 are characterized by abnormal bleeding due toSerpin E1 defect in the plasma. High concentrations of Serpin E1 have been associated with thrombophiliawhich is an autosomal dominant disorder in which affected individuals are prone to develop seriousspontaneous thrombosis.