Anti-Hu LAR APC

LAR is a receptore-linked transmembrane protein tyrosine phosphatase expressed on mesenchymal stem cells, that reside e.g. in bone marrow, blood, placenta, adipose tissue, or skin, as well as it is expressed on some carcinoma cell lines, including HeLa, MCF-7, or HT29. During the process of externalization, LAR is intracellularly proteolytically processed into two non-covalently associated subunits. This protein is involved in intercellular and cell-matrix interactions and its extracellular part resembles that of cell adhesion molecules (CAMs). The extracellular part can be released from the surface, which may be used for regulation of LAR function.

The mouse monoclonal antibody W7C6 recognizes an extracellular epitope of protein tyrosine phosphatase LAR, a marker of mesenchymal stem cells.

RUO

Mouse

Non-human primates,Human

WERI-RB-1 retinoblastoma cells

LAR

IgG1

W7C6

Flow cytometry: Recommended dilution: 1-4 μg/mL.

FC

0.1 mg/mL

APC

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

*Bühring HJ, Battula VL, Treml S, Schewe B, Kanz L, Vogel W: Novel markers for the prospective isolation of human MSC. Ann N Y Acad Sci. 2007 Jun1106:262-71. , URL: https://www.ncbi.nlm.nih.gov/pubmed/17395729,

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.